Neuroprotective effect of alcoholic extract of Selaginella bryopteris leaves in experimental models of epilepsy
Downloads
Published
DOI:
https://doi.org/10.58414/SCIENTIFICTEMPER.2024.15.4.14Keywords:
Antiepileptic, Selaginella bryopteris leaves Extract, Seizure Model, Neuroprotection, LC-MSDimensions Badge
Issue
Section
License
Copyright (c) 2024 The Scientific Temper

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Epilepsy, a neurological disorder, is characterized by recurrent, uncontrolled seizures due to an imbalance between inhibitory and excitatory neuronal interactions in the central nervous system (CNS). This study explores the neuroprotective effects of an alcoholic extract from Selaginella bryopteris leaves in experimental epilepsy models. Swiss albino mice (25–30 g) were used, and epilepsy was induced via pentylenetetrazol (PTZ, 60 mg/kg) and maximal electric shock (MES). The extract was administered orally at varying doses and compared with conventional antiepileptic drugs, phenytoin and diazepam. LC-MS analysis identified amentoflavone as a key bioactive compound with antiepileptic properties. The extract demonstrated significant dose-dependent protection in both PTZ and MES models, delaying convulsions in the PTZ model at 500 mg/kg, comparable to diazepam, and providing convulsion protection in the MES model similar to phenytoin. Additionally, the extract increased gamma-aminobutyric acid (GABA) and glutathione (GSH) levels while reducing lipid peroxidation (LPO) levels, indicating its neuroprotective properties. These findings suggest that S. bryopteris leaves possess significant antiepileptic properties and may serve as a promising treatment for epilepsy.Abstract
How to Cite
Downloads
Similar Articles
- Anju Bhatnagar, Assessment of antioxidant activity and phytochemical screening in leaf extract of Andrographis paniculate (Burm. f.) nees , The Scientific Temper: Vol. 14 No. 02 (2023): The Scientific Temper
- Temesgen A. Asfaw, Batch size impact on enset leaf disease detection , The Scientific Temper: Vol. 15 No. 01 (2024): The Scientific Temper
- Sahaya Jenitha A, Sinthu J. Prakash, A general stochastic model to handle deduplication challenges using hidden Markov model in big data analytics , The Scientific Temper: Vol. 14 No. 04 (2023): The Scientific Temper
- Divya R., Vanathi P. T., Harikumar R., An optimized cardiac risk levels classifier based on GMM with min- max model from photoplethysmography signals , The Scientific Temper: Vol. 15 No. 03 (2024): The Scientific Temper
- C. Muruganandam, V. Maniraj, A Self-driven dual reinforcement model with meta heuristic framework to conquer the iot based clustering to enhance agriculture production , The Scientific Temper: Vol. 15 No. 02 (2024): The Scientific Temper
- S. Sindhu, L. Arockiam, A lightweight selective stacking framework for IoT crop recommendation , The Scientific Temper: Vol. 15 No. 04 (2024): The Scientific Temper
- SHILPENDRA KOUR, REKHA KHANDAL, RASHMI TRIPATHI, EVALUATION OF LEAF EXTRACTS OF DIFFERENT MEDICINAL PLANTS FOR POTENTIAL ANTIBACTERIAL ACTIVITY AND PRELIMINARY PHYTOCHEMICAL ANALYSIS , The Scientific Temper: Vol. 3 No. 1&2 (2012): The Scientific Temper
- Annalakshmi D., C. Jayanthi, An asymmetric key encryption and decryption model incorporating optimization techniques for enhanced security and efficiency , The Scientific Temper: Vol. 15 No. 03 (2024): The Scientific Temper
- Rohit Mittal, Devinder Kumar, Harmel Singh Chahal, Antioxidant and Free Radical Scavenging Activity of Methanolic Extract of (Hordeum vulgare) Barley , The Scientific Temper: Vol. 13 No. 02 (2022): The Scientific Temper
- D. Padma Prabha, C. Victoria Priscilla, A combined framework based on LSTM autoencoder and XGBoost with adaptive threshold classification for credit card fraud detection , The Scientific Temper: Vol. 15 No. 02 (2024): The Scientific Temper
You may also start an advanced similarity search for this article.