Serological and Biochemical Profiling of Pandemic Dengue Virus in Clinical Isolates During An Outbreak in Dehradun Region

Published

25-07-2021

DOI:

https://doi.org/10.58414/SCIENTIFICTEMPER.2021.12.1.08

Keywords:

Dengue, DENV serotype, serological, IgG-IgM antibody, NS1 antigen, diagnosis, dengue infection, thrombocytopenia.

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Authors

  • Pallavi Dheer Department of Biotechnology, School of Basic and Applied Sciences, Shri Guru Ram Rai, University, Dehradun, Uttarakhand, India
  • Aditi Sharma Department of Biotechnology, Graphic Era University, Dehradun, Uttarakhand, India.
  • Mallika Joshi Department of Biotechnology, School of Basic and Applied Sciences, Shri Guru Ram Rai, University, Dehradun, Uttarakhand, India
  • Rajesh Rayal Department of Zoology, School of Basic and Applied Sciences, Shri Guru Ram Rai, University, Dehradun, Uttarakhand, India
  • Indra Rautela Department of Biotechnology, School of Applied and Life Sciences, Uttaranchal University, Dehradun, Uttarakhand, India
  • Rakesh Rai Department of Zoology, Buddh Snatkottar Mahavidyalay, Kushi Nagar, Uttar Pradesh, India
  • Narotam Sharma DNA-Lab, A Center for Applied Sciences, Dehradun, Uttarakhand, India

Abstract

Being the most prevalent, Dengue infection or Dengue fever is a mosquito-borne endemic-epidemic arboviral infection majorly found in the subtropical or tropical regions across the globe. With any of its 4 serotypes (DENV-1, DENV-2, DENV-3, & DENV-4), the dengue virus replicates within the vector; Aedes mosquito and is then transmitted to the human host through the bite. Past few decades have witnessed the escalation in the incidence of dengue infection cases by almost 30 fold. The present study involves the profiling from 60 clinical isolates during the outbreak in the dengue region. The study reveals serological and biochemical profiling of the clinical patient’s data. Out of the total studied 60 cases, 68.33% were males and 31.66% were females. The majority i.e. 40% of the cases belonged to the 21-30 years age group. The serological tests for the positive reactivity for antigen NS1 and antibodies IgG and IgM resulted out to be; 63%(NS1), 8%(IgG), 0(IgM), 7%(IgG-IgM), 17%(IgM-NS1), 3%(IgG-NS1), and 2%(IgG-IgM-NS1). The confirmed cases depicted thrombocytopenia.

How to Cite

Dheer, P., Sharma, A., Joshi, M., Rayal, R., Rautela, I., Rai, R., & Sharma, N. (2021). Serological and Biochemical Profiling of Pandemic Dengue Virus in Clinical Isolates During An Outbreak in Dehradun Region. The Scientific Temper, 12(1&2), . https://doi.org/10.58414/SCIENTIFICTEMPER.2021.12.1.08

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