Serological and Biochemical Profiling of Pandemic Dengue Virus in Clinical Isolates During An Outbreak in Dehradun Region

Abstract

Being the most prevalent, Dengue infection or Dengue fever is a mosquito-borne endemic-epidemic arboviral infection majorly found in the subtropical or tropical regions across the globe. With any of its 4 serotypes (DENV-1, DENV-2, DENV-3, & DENV-4), the dengue virus replicates within the vector; Aedes mosquito and is then transmitted to the human host through the bite. Past few decades have witnessed the escalation in the incidence of dengue infection cases by almost 30 fold. The present study involves the profiling from 60 clinical isolates during the outbreak in the dengue region. The study reveals serological and biochemical profiling of the clinical patient’s data. Out of the total studied 60 cases, 68.33% were males and 31.66% were females. The majority i.e. 40% of the cases belonged to the 21-30 years age group. The serological tests for the positive reactivity for antigen NS1 and antibodies IgG and IgM resulted out to be; 63%(NS1), 8%(IgG), 0(IgM), 7%(IgG-IgM), 17%(IgM-NS1), 3%(IgG-NS1), and 2%(IgG-IgM-NS1). The confirmed cases depicted thrombocytopenia.