To study references and analysis of an experimental model for skin burns in rats

Abstract

The purpose of the work: Review and systematization of scientific knowledge about the experimental model for skin burns in rats. Research methods: From 2018 to January 2022, a bibliographic analysis was conducted in a database that included international journals. Keywords used: A total of 289 studies on rat burn models were identified and 137 were selected. Results: Findings: 54/86 (62.7%) were third-degree burns; 55/103 (75.3%) were secondary; 45/78 (57.6%) were caused by boiling water and 27/78 (35.9%) by incandescent tools and 39/78 (50%) by systemic exposure. 42/116 (36.2%) received postoperative fluid therapy, and the time interval after the burn until the start of the analysis of the results was found to vary from 7 seconds to four weeks. Some issues of burning experiments were discussed. Conclusions: Hot water is the primary method of inducing third-degree burns with anesthesia using ketamine and xylazine after depilation. They were evaluated microscopically in the postoperative period without the use of analgesia or antibiotics. The studies were not very reproducible.